OUR COMPANY
DioTree is passionately dedicated to developing innovative treatment for high grade serous ovarian cancer (HGSOC), one of the deadliest human cancers with an extremely poor prognosis. Our groundbreaking approach involves the development of a first-of-its-kind small molecule technology designed to target and inhibit the enzyme DIO3, which drives ovarian cancer progression. We are committed to advancing the frontiers of cancer treatment and making a positive impact on the lives of those affected by this devastating disease.
OVARIAN CANCER
Ovarian cancer, which is the fourth most common cancer in women and the leading cause of death among tumors in the female reproductive system, currently lacks an effective treatment option beyond chemotherapy and surgery. Although PARP inhibitors have been developed, they are only effective for about 15% of cases, namely for women carrying the BRCA mutation. Annually, more than 300,000 new cases are diagnosed worldwide, 75% of which will not survive the disease.
Our company aims to target all ovarian cancer patients, including those who are non-carriers of the BRCA mutation or resistant to platinum-based chemotherapy. Our innovative drugs, which are "first-in-class" compounds designed to suppress the DIO3 enzyme, have potential applications beyond ovarian cancer, as DIO3 is expressed in other aggressive tumors such as lung, breast, colon, and pancreatic cancers. The target market size could potentially reach millions of cancer patients. Our product is expected to be integrated into the cancer treatment algorithm either as a combination therapy with chemotherapy drugs or as a maintenance therapy for patients who do not respond satisfactorily to current treatment options.
